Table 7 The selected helper T Cell epitopes of HPV L2 protein, based on binding affinity.
Protein Name | Position | Epitope Sequence | No. of Alleles | Top Alleles | NetMHCIIpan Average Rank Scores* | ProPred II Average Scores** | Conservancy (= > 75%) | Allergenicity |
|---|---|---|---|---|---|---|---|---|
L2 | 102–120 Type 16 | DPSIVSLVEETSFIDAGAP | 9 | DQA:10101 DQA:10102 | 8.120 | 1.257 | Type 33: 84.2% Type 35: 84.2% Type 58: 84.2% | Non-allergen |
100–118 Type 18 | DPSIVTLIEDSSVVTSGAP | 12 | DRB1:0401 DRB1:0301 DRB3:0101 | 7.980 | 1.315 | Type 45: 89.4% Type 59: 89.4% Type 39: 75.6% Type 51: 75.6% | Non-allergen | |
54–69 Type 16 | FFGGLGIGTGSGTGGR | 8 | DRB1:0402 DQA:10301 DQA:10501 | 7.160 | 1.645 | Type 58: 100% Type 18: 93.7% Type 31: 93.7% Type 33: 93.7% Type 35: 93.7% Type 59: 93.7% Type 68: 93.7% Type 39: 87.5% Type 45: 87.5% Type 51: 87.5% Type 52: 87.5% Type 56: 81.2% | Non-allergen | |
281–297 Type 16 | PDFLDIVALHRPALTSR | 32 | DRB5:0101 DRB4:0101 DRB1:0801 DRB1:0402 | 4.165 | 2.148 | Type 58: 100% Type 31: 94.1% Type 39: 94.1% Type 52: 94.1% Type 68: 94.1% Type 33: 88.2% Type 35: 88.2% Type 51: 88.2% Type 59: 88.2% Type 16: 76.4% Type 56: 76.4% | Non-allergen | |
274–290 Type 18 | SDFMDIIRLHRPALTSR | 26 | DRB1:0101 DRB1:0103 DRB1:0801 DRB1:1501 | 3.493 | 2.864 | Type 45: 94.1% Type 35: 88.2% Type 59: 88.2% Type 31: 82.3% Type 39: 82.3% Type 51: 82.3% Type 52: 82.3% Type 68: 82.3% Type 16: 76.4% Type 33: 76.4% Type 58: 76.4% | Non-allergen |
