Table 8 Proteasomal cleavage and TAP transport efficiency scores of MHC-I predicted epitopes.

From: In silico/In vivo analysis of high-risk papillomavirus L1 and L2 conserved sequences for development of cross-subtype prophylactic vaccine

Protein Name

Position

Epitope Sequence

Proteasomal C terminal cleavage Score*

TAP transport efficiency Score**

Epitope identification Score***

L1

12–21 (Type 16)

YLPPVPVSKV

1.0473

0.9771

1.3162

12–21 (Type 18)

YLPPPSVARV

0.9753

0.8581

0.9656

114–125 (Type 16)

GVGISGHPLLNK

0.8023

0.6695

0.7094

104–115 (Type 18)

GVEIGRGQPLGV

0.5253

0.9200

0.7017

114–125 (Type 18)

GVGLSGHPFYNK

0.3726

0.9360

0.6484

411–421 (Type 16)

GGTLEDTYRFV

0.5795

0.9599

0.8396

414–425 (Type 18)

PTTSLVDTYRFV

0.5992

0.9267

0.7579

460–470 (Type 16)

DQFPLGRKFLL

0.9879

0.9810

1.2046

461–471 (Type 18)

DQYPLGRKFLV

0.9358

0.9606

1.0779

L2

11–20 (Type 16)

KRASATQLYK

1.3081

0.9773

1.6173

11–20 (Type 18)

KRASVTDLYK

1.1145

0.9726

1.4230

60–71 (Type 18)

GTGSGTGGRTGY

0.4471

0.4000

0.5630

280–291 (Type 16)

DPDFLDIVALHR

0.8251

0.9405

1.0209

293–303 (Type 16)

ALTSRRTGIRY

0.6667

0.9280

0.8580

273–284 (Type 18)

DSDFMDIIRLHR

0.6514

0.9917

0.8881

286–296 (Type 18)

ALTSRRGTVRF

0.6545

0.8565

0.7305

  1. *Higher rates show better quality of proteasomal cleavage, **Higher rates show better quality of tap transport efficiency, *** Higher rates show better quality of epitope identification.