Table 2 Genes harboring k-mers significantly associated with different phenotypes (from (1) to (6)) in Hanoi and KwaZulu-Natal studies.

From: Whole genome sequencing, analyses of drug resistance-conferring mutations, and correlation with transmission of Mycobacterium tuberculosis carrying katG-S315T in Hanoi, Vietnam

Phenotype

Gene name

Number of genes

(1)

(2)

(3)

(4)

(5)

(6)

No

Yes

Yes

Yes

Yes

Yes

gid

1

No

Yes

No

Yes

No

Yes

rrs

1

No

Yes

Yes

No

Yes

No

katG

1

No

No

Yes

Yes

Yes

Yes

PPE18, Rv1148c

2

Yes

No

Yes

No

No

No

ephB, glpK, mce1A

3

No

No

Yes

No

No

Yes

emrB, mmpL6, Rv1588c

3

No

No

Yes

Yes

No

Yes

PE_PGRS10, PE_PGRS21, PE_PGRS53, pks12, pncA, rpoB, Rv2090, wag22

8

No

No

No

Yes

No

Yes

atsD, fabG1, gyrA, helZ, murF, PE_PGRS52, Rv2000, Rv2161c, Rv3471c, ubiA

10

No

No

No

Yes

Yes

Yes

ctpB, drrA, ethA, fhaA, PPE19, PPE60, Rv0094c, Rv1945, Rv2019, Rv2141c, Rv3921c

11

No

Yes

Yes

No

No

No

accD2, eccC3, eccC4, fadE7, fas, glfT1, icd1, lepB, lprN, mbtJ, mce1R, menA, mez, PE_PGRS42, PPE30, PPE4, PPE54, rbsK, Rv1106c, Rv1147, Rv1215c, Rv1747, Rv2005c, Rv2566, Rv3085, Rv3401, Rv3677c, yfiH, zwf1

29

No

No

No

No

Yes

No

fadD5, Rv0336, Rv0348

3

Yes

No

No

No

No

No

atsA, gltA2, PE_PGRS12, Rv3863

4

No

Yes

No

No

No

No

mycP2, rpsL, Rv0012, Rv0219, Rv0893c, Rv1217c, Rv1443c, Rv1515c, Rv1516c, Rv2033c, Rv2277c, Rv2672, Rv2825c, Rv3177, Rv3618, yjcE

16

No

No

No

No

No

Yes

cysK1, espI, glmS, hsaA, lprQ, PE23, pks15, pks7, pmmB, rhlE, Rv0121c, Rv1073, Rv1639c, Rv2219, Rv3217c, Rv3254, Rv3660c, Rv3707c, thiL, vapB34

20

No

No

Yes

No

No

No

35kd_ag, accA3, adhE1, aglA, aldA, alkB, alr, amiB2, amiC, aprA, aroA, aroG, arsA, arsB2, bfrA, bfrB, blaC, cdh, cobN, cut1, cyp139, cysA2, cysD, deoC, devS, dinF, dinG, dinX, dnaB, dnaE2, dnaG, dnaK, dxs2, eccA3, eccB2, eccC2, eccD5, efp, egtE, eno, erg3, espH, esxJ, esxK, esxM, etgB, fadB3, fadB4, fadD15, fadD18, fadD22, fadD24, fadE18, fadE25, fadE34, fbiC, fecB, folC, frdD, fusA1, gatB, gcvB, glgA, gnd2, groEL2, guaB1, guaB2, hemB, hemY, hisH, hupB, hycQ, iniC, ispD, kshA, lepA, leuA, lipD, lipP, lppA, lppH, lppZ, lpqH, lprA, ltp1, mbtE, mce3B, mce3C, mcr7, menC, metH, mmpL1, mmpL11, mmpL5, mmsA, mmuM, moeB1, murE, mutT3, mymT, narG, nlhH, nrp, oppB, oxyR, papA2, papA5, PE_PGRS1, PE_PGRS13, PE_PGRS16, PE_PGRS17, PE_PGRS19, PE_PGRS2, PE_PGRS22, PE_PGRS23, PE_PGRS24, PE_PGRS25, PE_PGRS26, PE_PGRS27, PE_PGRS30, PE_PGRS31, PE_PGRS32, PE_PGRS33, PE_PGRS38, PE_PGRS4, PE_PGRS43, PE_PGRS44, PE_PGRS45, PE_PGRS46, PE_PGRS47, PE_PGRS48, PE_PGRS50, PE_PGRS54, PE_PGRS55, PE_PGRS56, PE_PGRS57, PE_PGRS6, PE_PGRS62, PE_PGRS7, PE_PGRS9, PE1, pepC, pepD, pepR, php, pknB, pknJ, pknK, pknL, pks13, pks9, pncB2, pntAb, ppa, PPE11, PPE12, PPE15, PPE21, PPE24, PPE34, PPE42, PPE46, PPE55, PPE56, PPE57, PPE59, PPE6, PPE8, ppm1, ppnK, ppsA, ppsC, proV, prpD, psd, purH, purL, purT, recC, relE, rfe, rimJ, rpfA, rpsD, Rv0057, Rv0060, Rv0074, Rv0095c, Rv0111, Rv0133, Rv0149, Rv0178, Rv0180c, Rv0188, Rv0192, Rv0193c, Rv0203, Rv0218, Rv0238, Rv0257, Rv0278c, Rv0302, Rv0323c, Rv0339c, Rv0367c, Rv0378, Rv0386, Rv0412c, Rv0457c, Rv0474, Rv0477, Rv0492c, Rv0537c, Rv0538, Rv0575c, Rv0584, Rv0647c, Rv0650, Rv0658c, Rv0686, Rv0696, Rv0740, Rv0790c, Rv0842, Rv0845, Rv0874c, Rv0876c, Rv0921, Rv0939, Rv0996, Rv1004c, Rv1024, Rv1043c, Rv1045, Rv1047, Rv1048c, Rv1050, Rv1069c, Rv1085c, Rv1178, Rv1225c, Rv1273c, Rv1313c, Rv1318c, Rv1372, Rv1395, Rv1425, Rv1455, Rv1488, Rv1498A, Rv1499, Rv1526c, Rv1610, Rv1667c, Rv1683, Rv1702c, Rv1707, Rv1714, Rv1725c, Rv1726, Rv1728c, Rv1729c, Rv1739c, Rv1749c, Rv1815, Rv1825, Rv1828, Rv1831, Rv1835c, Rv1879, Rv1895, Rv1941, Rv1999c, Rv2017, Rv2023A, Rv2024c, Rv2025c, Rv2038c, Rv2074, Rv2134c, Rv2143, Rv2164c, Rv2177c, Rv2190c, Rv2219A, Rv2228c, Rv2254c, Rv2256a, Rv2286c, Rv2314c, Rv2319c, Rv2327, Rv2424c, Rv2456c, Rv2532c, Rv2556c, Rv2567, Rv2621c, Rv2630, Rv2638, Rv2656c, Rv2668, Rv2669, Rv2729c, Rv2733c, Rv2792c, Rv2798c, Rv2851c, Rv2864c, Rv2893, Rv2897c, Rv2951c, Rv2974c, Rv2994, Rv3027c, Rv3060c, Rv3064c, Rv3074, Rv3104c, Rv3169, Rv3193c, Rv3201c, Rv3208, Rv3216, Rv3218, Rv3230c, Rv3263, Rv3365c, Rv3400, Rv3439c, Rv3549c, Rv3668c, Rv3689, Rv3717, Rv3728, Rv3729, Rv3807c, Rv3856c, Rv3896c, Rv3898c, sirA, smc, tal, TB9.4, tgs2, thiD, tig, treX, trxB1, uspC, uvrA, vapB36, vapC29, whiA, yrbE3A, yrbE3B

356

  1. Phenotype (1): clustered strains (cluster[+]) (pairwise SNV difference between two isolates is no more than five SNVs) in Hanoi’s study cohort; (2): strains harboring katG-S315 T mutation (S315 T[+]) in Hanoi’s cohort; (3): cluster[+]/S315T[+] in Hanoi’s cohort; (4): cluster[+] in KwaZulu-Natal’s cohort; (5) S315T[+] in KwaZulu-Natal’s cohort; (6): cluster[+]/S315T[+] in KwaZulu-Natal’s cohort; SNV: single nucleotide variant.
  2. The genes in bold are associated with cluster[+]/S315T[+], and shared between Hanoi and KwaZulu-Natal study population.