Figure 4 | Scientific Reports

Figure 4

From: Modeling Snyder-Robinson Syndrome in multipotent stromal cells reveals impaired mitochondrial function as a potential cause for deficient osteogenesis

Figure 4

Silencing SMS affects mitochondrial function. Transduced MSCs were cultured in serum-free media containing 5.5 mM glucose and no lactose. After 24 hours, supernatants were collected to determine levels of glucose (A) and lactose (B) (n = 7). Statistical differences were calculated using paired Student’s t test, where * p < 0.05. (C) Transduced MSCs as seen under TEM. At least 10 cells per condition were examined in detail, finding consistently more fusing mitochondrion (arrows) in SMS-deficient cells (shSMS). N = nucleus. Scale bar = 1 μm.

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