Table 1 The comparison of the analytical potential of FTIR, RS and AFM in the thrombi studies.

lipid content

• distribution within the whole cross–section

• qualitative or semi–quantitative detection

• distribution with hi–res for chosen ROI

• qualitative measurement

• form of lipids (crystals/grease material)

^{10, 18, 23}

the total degree of lipids unsaturation

• semi–quantitative measurement for whole cross–section

• semi–quantitative measurement with hi–res for chosen ROI

–

^{38, 39}

general proteins content

• distribution for whole cross–section

• qualitative or quantitative measurement

• distribution with hi–res for chosen ROI

• qualitative or semi–quantitative measurement

• height and topography/stiffness of tissue

¹⁴

the ratio of lipids to proteins

• semi–quantitative measurement for whole cross–section

• semi–quantitative measurement with hi–res for chosen ROI

–

^{11, 12}

fibrin content

• distribution for whole cross–section

• qualitative measurement

• in order to build the model necessary to compare with H&E

• distribution with hi–res for chosen ROI

• qualitative measurement

• in order to build the model necessary to compare with H&E

• fibrin height and topography/stiffness

^{10, 13, 40, 41}

RBCs/heme

• distribution for whole cross–section

• qualitative measurement

• distribution with hi–res for chosen ROI

• qualitative measurement

• high specificity and sensitivity to heme due to resonance effect

• height and topography/stiffness

^{42, 43}