Figure 2

Landscape of somatic variants and gene set expression signatures in sensitive, resistant, and acquired-resistant tumours. (a,b) Somatic variants identified in genes grouped by molecular pathways. MUT, non-synonymous single nucleotide or small indel mutation; FUS, gene fusion; AMP, copy number amplification (CN ≥4). The top bar chart shows the tumour mutation burden of non-synonymous somatic variants. Amino acid change is shown for a subset of genes in (b). (c) Hierarchical clustering of gene set expression signatures for a panel of published molecular signatures (see Methods). The Z score represents both the magnitude and relative direction of a signature’s expression. Baseline tumour (T), acquired-resistant tumour (RT).