Figure 1 | Scientific Reports

Figure 1

From: Chemical activation of divergent protein tyrosine phosphatase domains with cyanine-based biarsenicals

Figure 1

Design of chemically activatable (act) PTPs. (A) In actPTPs, three cysteines are engineered at non-conserved residues within the WPD loop to create a tricysteine motif. Engagement of a biarsenical ligand with the engineered binding site on the WPD loop enhances actPTP activity while wild-type activity is unaffected. (B) Primary sequence alignment of the WPD loops of wild-type PTPs. In the WPD loop sequence of actPTPs, cysteines replace the positions colored in red. (C) Chemical structures of four biarsenicals used to target actPTPs.

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