Figure 8 | Scientific Reports

Figure 8

From: Chemical activation of divergent protein tyrosine phosphatase domains with cyanine-based biarsenicals

Figure 8

K556G actPTPRR is strongly activated by AsCy3. (A) Primary sequence of the WPD loop of K556G actPTPRR. The location of the glycine mutation is highlighted in green. (B) PTP activity of K556G actPTPRR (200 nM) was measured with pNPP (2 mM, quenched assay) in the absence (DMSO) or presence of the indicated biarsenicals (1 µM) after 60-minute pre-incubations.

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