Table 3 Levels of the most discriminative metabolites (VIP >3) for RCC subtype classification.
From: LC-MS based metabolomic profiling for renal cell carcinoma histologic subtypes
Name | m/z | Mode | VIP | Peak intensity | Ratio | Peak Intensity | Ratio | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Mean cc | Mean pap | Mean chro | pap/cc | chro/cc | pap/chro | Mean Healthy | RCC/Healthy | ||||
Creatine | 132.07694 | POS | 10.51 | 2.98E + 09 | 1.31E + 09 | 4.92E + 09 | 0.44 | 1.65 | 0.27* | 2.06E + 09 | 1.26 |
L-Acetylcarnitine | 204.12320 | POS | 10.43 | 4.50E + 09 | 1.91E + 09 | 3.13E + 09 | 0.42** | 0.7 | 0.61 | 2.90E + 09 | 1.24 |
L-Carnitine | 162.11262 | POS | 6.85 | 2.18E + 09 | 1.03E + 09 | 1.79E + 09 | 0.47* | 0.82 | 0.58 | 1.34E + 09 | 1.82 |
L-Proline | 116.07095 | POS | 6.45 | 1.39E + 09 | 2.06E + 09 | 8.66E + 08 | 1.48* | 0.62 | 2.38*** | 1.56E + 09 | 0.71* |
L-Phenylalanine | 166.08636 | POS | 6.07 | 1.44E + 09 | 2.07E + 09 | 1.09E + 09 | 1.43 | 0.76 | 1.90* | 2.09E + 09 | 0.51* |
Betaine | 118.08658 | POS | 5.15 | 2.10E + 09 | 2.46E + 09 | 1.82E + 09 | 1.17 | 0.87 | 1.35 | 1.71E + 09 | 1.44 |
Hypoxanthine | 137.04591 | POS | 5.11 | 1.21E + 09 | 1.95E + 09 | 1.79E + 09 | 1.61* | 1.48 | 1.09 | 3.26E + 09 | 0.54** |
L-Lactic acid | 89.02295 | NEG | 5 | 3.45E + 09 | 3.87E + 09 | 3.55E + 09 | 1.12 | 1.03 | 1.09 | 2.16E + 06 | 0.8 |
L-Isoleucine | 132.10212 | POS | 4.65 | 1.44E + 09 | 1.51E + 09 | 8.21E + 08 | 1.05 | 0.57 | 1.83* | 1.26E + 09 | 0.56** |
Glycerophosphocholine | 296.06608 | POS | 4.03 | 4.80E + 08 | 5.79E + 08 | 8.33E + 08 | 1.21 | 1.73 | 0.7 | 2.86E + 08 | 2.06 |
L-Methionine | 150.05848 | POS | 3.89 | 2.18E + 08 | 6.83E + 08 | 2.83E + 08 | 3.14** | 1.3 | 2.41* | 6.15E + 08 | 0.36** |
L-Tyrosine | 182.08135 | POS | 3.7 | 3.99E + 08 | 7.36E + 08 | 3.26E + 08 | 1.85** | 0.82 | 2.26*** | 9.71E + 08 | 0.49* |
L-Palmitoylcarnitine | 400.34272 | POS | 3.66 | 4.48E + 08 | 1.05E + 08 | 1.84E + 08 | 0.23** | 0.41 | 0.57 | 1.17E + 08 | 0.96 |
Dimethylglycine | 104.07109 | POS | 3.63 | 4.50E + 08 | 3.42E + 08 | 3.94E + 07 | 0.76 | 0.09*** | 8.67* | 1.28E + 08 | 1.01 |
L-Tryptophan | 205.09736 | POS | 3.4 | 4.34E + 08 | 6.37E + 08 | 2.85E + 08 | 1.47 | 0.66 | 2.24* | 7.77E + 08 | 0.41** |
Hydroxybutyrylcarnitine | 248.14922 | POS | 3.22 | 4.08E + 08 | 1.22E + 08 | 5.12E + 08 | 0.3 | 1.26 | 0.24 | 2.50E + 08 | 2.62* |
N-Acetyl-L-aspartic acid | 174.03976 | NEG | 3.21 | 3.81E + 07 | 8.15E + 07 | 3.57E + 08 | 2.14 | 9.37** | 0.23* | 5.97E + 08 | 0.29* |
Adenosine | 268.10419 | POS | 3.19 | 1.19E + 08 | 1.09E + 08 | 4.88E + 08 | 0.91 | 4.1 | 0.22 | 1.45E + 08 | 1.37 |
L-Malic acid | 133.01299 | NEG | 3.19 | 4.93E + 08 | 2.53E + 08 | 2.23E + 08 | 0.51 | 0.45* | 1.14 | 5.19E + 08 | 0.63 |
Isobutyryl-L-carnitine | 232.15447 | POS | 3.14 | 4.66E + 08 | 3.39E + 08 | 6.25E + 08 | 0.73 | 1.34 | 0.54 | 4.82E + 08 | 1.39 |
L-Glutamic acid | 148.06055 | POS | 3.07 | 1.09E + 09 | 7.98E + 08 | 5.56E + 08 | 0.73 | 0.51 | 1.43 | 7.57E + 08 | 1.26 |
