Figure 7
Glucocorticoids reduce TGF-β1-induced HSP47 and extracellular matrix expression in ex vivo organ cultures of nasal inferior turbinates. Nasal inferior turbinate tissues were organ cultured with or without dexamethasone (5 μM) and fluticasone propionate (5 μM) and then treated with TGF-β1 (2 ng/mL) in ex vivo organ cultures of nasal inferior turbinates (n = 6). (A) The mRNA levels for HSP47 and ECM-related markers were evaluated using real-time PCR. (B) Shown are representative western blots for HSP47 and ECM-related markers. Data are expressed as the mean ± SEM of three independent experiments. *p < 0.05 vs. control; †p < 0.05 vs. TGF-β1.
