Table 3 Analyses of allele combinations of AGO1 and AGO2 polymorphisms in RPL patients and controls.
From: Association study of AGO1 and AGO2 genes polymorphisms with recurrent pregnancy loss
Allele combinations | Controls (2n = 492) | RPL patients (2n = 770) | OR (95%CI) | P |
|---|---|---|---|---|
AGO1 rs595961G>A/AGO1 rs636832A>G/AGO2 rs2292779C>G/AGO2 rs4961280C>A | ||||
G-A-C-C | 223 (45.4) | 311 (40.3) | 1.000 (reference) | |
G-A-C-A | 6 (1.3) | 31 (4.0) | 3.705 (1.520–9.032) | 0.002 |
G-A-G-C | 107 (21.8) | 201 (26.1) | 1.347 (1.007–1.802) | 0.045 |
G-A-G-A | 14 (2.9) | 22 (2.9) | 1.127 (0.564–2.251) | 0.735 |
G-G-C-C | 37 (7.6) | 52 (6.8) | 1.008 (0.639–1.589) | 0.974 |
G-G-C-A | 2 (0.5) | 4 (0.5) | 1.434 (0.260–7.901) | 1.000 |
G-G-G-C | 40 (8.1) | 22 (2.8) | 0.394 (0.228–0.682) | 0.001 |
G-G-G-A | 0 (0.0) | 3 (0.4) | 5.022 (0.258–97.790) | 0.270 |
A-A-C-C | 20 (4.1) | 5 (0.6) | 0.179 (0.066–0.485) | 0.0003 |
A-A-C-A | 4 (0.9) | 1 (0.1) | 0.179 (0.020–1.616) | 0.167 |
A-A-G-C | 16 (3.2) | 4 (0.5) | 0.179 (0.059–0.544) | 0.001 |
A-A-G-A | 1 (0.3) | 0 (0.0) | 0.239 (0.010–5.903) | 0.419 |
A-G-C-C | 13 (2.7) | 75 (9.8) | 4.137 (2.240–7.641) | <0.0001 |
A-G-C-A | 1 (0.3) | 8 (1.0) | 5.736 (0.712–46.210) | 0.089 |
A-G-G-C | 4 (0.9) | 32 (4.2) | 5.736 (2.000–16.460) | 0.0002 |
AGO1 rs595961G>A/AGO1 rs636832A>G/AGO2 rs2292779C>G | ||||
G-A-C | 206 (41.9) | 341 (44.3) | 1.000 (reference) | |
G-A-G | 114 (23.2) | 224 (29.1) | 1.187 (0.893–1.577) | 0.237 |
G-G-C | 64 (13.1) | 56 (7.3) | 0.529 (0.355–0.787) | 0.002 |
G-G-G | 47 (9.5) | 25 (3.2) | 0.321 (0.192–0.538) | <0.0001 |
A-A-C | 25 (5.1) | 5 (0.7) | 0.121 (0.046–0.321) | <0.0001 |
A-A-G | 14 (2.8) | 3 (0.5) | 0.130 (0.037–0.456) | 0.001 |
A-G-C | 13 (2.7) | 84 (10.9) | 3.903 (2.122–7.179) | <0.0001 |
A-G-G | 9 (1.8) | 31 (4.1) | 2.081 (0.971–4.459) | 0.055 |
AGO1 rs595961G>A/AGO1 rs636832A>G/AGO2 rs4961280C>A | ||||
G-A-C | 330 (67.1) | 512 (66.5) | 1.000 (reference) | |
G-A-A | 21 (4.4) | 53 (6.9) | 1.627 (0.963–2.747) | 0.067 |
G-G-C | 79 (16.0) | 74 (9.6) | 0.604 (0.427–0.853) | 0.004 |
G-G-A | 1 (0.2) | 7 (0.9) | 4.512 (0.552–36.860) | 0.160 |
A-A-C | 35 (7.2) | 8 (1.1) | 0.147 (0.067–0.322) | <0.0001 |
A-A-A | 6 (1.2) | 0 (0.1) | 0.050 (0.003–0.884) | 0.004 |
A-G-C | 18 (3.6) | 106 (13.8) | 3.796 (2.260–6.375) | <0.0001 |
A-G-A | 2 (0.3) | 9 (1.2) | 2.900 (0.623–13.510) | 0.218 |
AGO1 rs595961G>A/AGO2 rs2292779C>G/AGO2 rs4961280C>A | ||||
G-C-C | 260 (52.8) | 364 (47.2) | 1.000 (reference) | |
G-C-A | 9 (1.8) | 35 (4.5) | 2.778 (1.312–5.879) | 0.006 |
G-G-C | 149 (30.2) | 222 (28.8) | 1.064 (0.819–1.382) | 0.641 |
G-G-A | 14 (2.9) | 26 (3.3) | 1.327 (0.679–2.590) | 0.406 |
A-C-C | 33 (6.7) | 79 (10.3) | 1.710 (1.105–2.646) | 0.015 |
A-C-A | 7 (1.5) | 9 (1.1) | 0.918 (0.338–2.498) | 0.868 |
A-G-C | 20 (4.2) | 36 (4.7) | 1.286 (0.728–2.272) | 0.386 |
AGO1 rs595961G>A/AGO1 rs636832A>G | ||||
G-A | 320 (65.1) | 565 (73.4) | 1.000 (reference) | |
G-G | 111 (22.5) | 81 (10.5) | 0.413 (0.301–0.568) | <0.0001 |
A-A | 39 (7.9) | 9 (1.2) | 0.131 (0.062–0.273) | <0.0001 |
A-G | 22 (4.5) | 115 (15.0) | 2.961 (1.839–4.767) | <0.0001 |
AGO1 rs595961G>A/AGO2 rs2292779C>G | ||||
G-C | 270 (55.0) | 398 (51.7) | 1.000 (reference) | |
G-G | 161 (32.7) | 248 (32.3) | 1.045 (0.813–1.344) | 0.732 |
A-C | 39 (7.9) | 88 (11.5) | 1.531 (1.018–2.301) | 0.040 |
A-G | 22 (4.5) | 36 (4.6) | 1.110 (0.639–1.929) | 0.711 |
AGO1 rs595961G>A/AGO2 rs4961280C>A | ||||
G-C | 408 (83.0) | 586 (76.1) | 1.000 (reference) | |
G-A | 23 (4.6) | 60 (7.8) | 1.816 (1.105–2.986) | 0.017 |
A-C | 54 (10.9) | 115 (14.9) | 1.483 (1.048–2.098) | 0.026 |
A-A | 7 (1.5) | 9 (1.2) | 0.895 (0.331–2.424) | 0.827 |
