Figure 2 | Scientific Reports

Figure 2

From: Kinetic Control of Parallel versus Antiparallel Amyloid Aggregation via Shape of the Growing Aggregate

Figure 2

Cartoon showing binding free energies for interfaces in the a (backbone axis), b (sidechain axis) and c (hydrogen bond axis). (a–d) AP structure has generic in-register steric zipper 3D assembly. (e–f) Sievers’ structure has herringbone assembly characterised by two energy terms ε and ε′. In Sievers’ structure the binding free energies in a and b directions are (e) ΔG = (2nb−1)ε/2 and (f) ΔG = (na−1)ε + naε′, where na and nb are the number of peptides in a and b directions, respectively. [Graphics produced with pymol 1.8 http://pymol.org and inkscape 0.91 http://inkscape.org].

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