Figure 2
From: The HIV protease inhibitor darunavir prevents kidney injury via HIV-independent mechanisms
DRV reduced histologic glomerular and tubulointerstitial injury in Tg26 mice. Control-treated Tg26 kidneys had glomerulosclerosis (arrow) and tubulointerstitial injury with tubular casts (#), tubular atrophy (red arrowhead), and interstitial inflammation (black arrowhead) typical of the HIVAN phenotype. These changes were less severe in DRV- and DRV + AZT-treated Tg26 mice (A). Quantitative histomorphometric analyses of PAS-stained sections demonstrated that each of these indices were markedly elevated in Tg26 mice given vehicle control but DRV and DRV + AZT treated Tg26 mice had significantly reduced severity in all parameters of histologic injury compared to vehicle-treated Tg26 mice (B-E). AZT-treated mice did not have significantly improved tubular cast formation (C) or interstitial inflammation (E) but did have reduced glomerulosclerosis (B) and interstitial fibrosis and tubular atrophy (D) compared to control-treated Tg26 mice. *p < 0.05 vs control. Scale bar, 25 µm.
