Table 3 Protein targets for drug repositioning. E. granulosus H-PSCs up-regulated proteins for which there are available inhibitory drugs previously used for the treatment of different infections/diseases.

Glycerol-3-phosphate dehydrogenase

Anacardic acids

Non-competitive enzyme inhibition

Tumors and Bacterial pathogens

¹⁰⁸

Carbonyl reductase

Biphenyl compounds

Enzyme inhibition

Breast cancer

¹⁰⁹

Cathepsin D

Amprenavir^a, Indinavir^a, Lopinavir^a, Nelfinavir^a, Ritonavir^a, Saquinavir^a

Enzyme inhibition

Human Immunodeficiency Virus Trypanosomatids: Leishmania species and T. cruzi

^{110, 111}

Estradiol 17-beta dehydrogenase

Steroidal STX1040 and non-steroidal PBRM

Enzyme inhibition

Breast cancer

¹¹²

Glutathione-S-transferase

Ethacrynic acid analogues^a

Enzyme inhibition

Cancers

¹¹³

Glutathione analogues: ezatiostat (TLK199)

Myelodysplastic syndrome

¹¹⁴

Proteasome subunits

Bortezomib^a

Inhibition of p53 degradation?

Multiple myeloma

¹¹⁵

Epoxomicin

Proteasome inhibition

Babesia divergens

¹¹⁶

Carmaphycin B analogs

Proteasome inhibition

Plasmodium falciparum

¹¹⁷