Figure 2
From: Hif1a and Hif2a can be safely inactivated in cone photoreceptors
Retinal gene expression in RD∆Hif1a and AC∆Hif1a mice during ageing. (a) HIF1-responsive genes (Vegf, Egln1, Adm) and Epas1 (Hif2a). (b) Cone-specific genes (Opn1sw, Opn1mw) and genes involved in degeneration (Casp1), gliosis (Gfap) or inflammation (Ccl2). Expression was determined in RD∆Hif1a and AC∆Hif1a and their respective controls at 4, 8, 12 and 26 weeks of age (as indicated). Expression levels were normalized to Actb and shown relative to 4-week-old RDctrl mice, the levels of which were set to 1 (dotted line). Shown are means ± SD of n = 3. Significance between knockdown and control mice was calculated at every individual time point by two-way ANOVA with Å Ãdák’s multiple comparison test *p < 0.05; **p < 0.01; ***p < 0.001.
