Figure 4
From: Hif1a and Hif2a can be safely inactivated in cone photoreceptors
Retinal function in RD∆Hif1a and AC∆Hif1a mice. Averaged light-adapted (a–d) and dark-adapted (e,f) single flash ERG traces of RDΔHif1a and ACΔHif1a mice and their respective control littermates. A- and b-wave amplitudes were plotted as a function of light intensity (right panels, a–f). Photopic (a,b) and scotopic (e,f) single white-light flash intensity series at 12- (a,e) and 26- (b,f) weeks of age. Photopic single UV-light flash intensity series in 3-month-old RDΔHif1a (c) and ACΔHif1a (d) mice and their respective control littermates. Shown are means ± SD of n ≥ 3 (ctrl/kd = a (RD 5/4; AC 4/3); b (RD 4/4; AC 4/4); c (6/6); d (3/3); e (4/4); f (4/4)). Two-way ANOVA with Å Ãdák’s multiple comparison test was used for statistical analysis. *p < 0.05; **p < 0.01.
