Figure 2

(a) Heatmap of pathways with AUC > 0.98 in separating normal (n = 144) and tumour samples (n = 1971). Blue and red colours indicate low and high PathTracer score, respectively. (b) Heatmap of pathways with AUC > 0.7 in separating tumour samples with (n = 387) and without (n = 1008) TP53-mutation. Blue and red colours indicate low and high PathTracer score, respectively. (c) Kaplan Meier curves of breast cancer specific surivival for the Metabric dataset for the six clusters identified in (a). (d) Kaplan Meier curves of breast cancer specific survival for the Metabric dataset with tumour samples only, for the five clusters identified in (b).