Figure 3
From: PathTracer: High-sensitivity detection of differential pathway activity in tumours
(a) Box plots of the Pearson correlation between deregulation scores (PTS/PDS) and Genome Instability Index (GII) (left) and proliferation index (right) using the Metabric dataset with n = 1971 tumour samples and n = 144 normal samples and 1288 human Reactome pathways. (b) Projection of samples onto the principal curve for the Cell cycle pathway using the Metabric dataset. The samples are coloured according to PAM50 subtype. The median PahtTracer score for each subtype is given by the length of the dotted lines. (c) Comparison of Pathifier (PDS) and PahtTracer (PTS) deregulation scores for each of the PAM50 subtypes using the Metabric dataset. (d) Projection of samples onto the principal curve for the DNA repair pathway using the Metabric dataset. The samples are coloured according to PAM50 subtype. The median PathTracer score for each subtype is given by the length of the dotted lines. (e) Comparison of Pathifier (PDS) and PahtTracer (PTS) deregulation scores for each of the PAM50 subtypes using the Metabric dataset.
