Figure 7
Representation of influenza vaccine-induced changes in urine metabolites related to nicotinamide (a) trimethylamine metabolism (b) and the tricarboxylic acid (TCA) cycle. (c) Each of the graphs shows a comparison of the urine metabolite levels from mice treated with sterilized physical saline (SA), 15 μg hemagglutinin (HA)-containing hemagglutinin split vaccine (HAV), or 1.0 U of the toxicity reference vaccine (RE). *p < 0.05 and **p < 0.01 (n = 5 in the SA or RE group and n = 3 in the HAV group).
