Table 1 Body weight loss, leukopenic toxicity and plasma alanine aminotransferase (ALT) level changes after different strains of influenza vaccine injection.

From: Changes of urine metabolite profiles are induced by inactivated influenza vaccine inoculations in mice

 

SA

HAVH1N1-15 μg HA

HAVH3N2-15 μg HA

HAV B/Yamagata-15 μg HA

WPV H1N1-15 μg HA

WPV H3N2-15 μg HA

WPV B/Yamagata-15 μg HA

RE 1.0 U

Body weight change (g)

0.98 ± 0.13

0.78 ± 0.25

0.53 ± 0.27

0.73 ± 0.18

−0.15 ± 0.13**

−0.05 ± 0.15**

0.05 ± 0.23*

−0.23 ± 0.15**

White blood cells (cells/μl blood)

5525 ± 464

5450 ± 312

6275 ± 415

6050 ± 184

1050 ± 64***

990 ± 112***

935 ± 129***

962 ± 170***

Alanine aminotransferase (U/l) activity

40.3 ± 6.4

43.8 ± 4

39.8 ± 6.9

41.8 ± 6.5

75.8 ± 13.5*

87.0 ± 9.2**

78.0 ± 12.1*

87.8 ± 8.7**

  1. The unit of the dose for hemagglutinin (HA) in the hemagglutinin split vaccine (HAV) was μg and that for the toxicity reference vaccine (RE) was U.
  2. Data are indicated as the mean ± SEM. (n = 4) *P < 0.05, **P < 0.01, and ***P < 0.001 compared with the sterilized physical saline (SA) group.
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