Figure 10
From: Mild chronic perturbation of inhibition severely alters hippocampal function
Diazepam reduces overall EEG power selectively in γ2* animals. (A) Active wake power spectra from WT animals (n = 11) before (solid line) and after (dashed line) non-sedative diazepam injections (0.75 mg/kg). (B) Effect of diazepam on power of indicated EEG bands in WT animals. (C) Active wake power spectra from γ2* animals (n = 9) before and after non-sedative diazepam injections, inset percent difference of active wake power spectra from WT baseline, of WT after diazepam (black dashed line), γ2* baseline (red solid line), and γ2* after diazepam (red dashed line). (D) Effect of diazepam on EEG band power in γ2* animals. The result of a three-way ANOVA showed a significant interaction among frequency, genotype, and drug (F, (4, 90) = 5.25, P = 7e-4) and between drug and genotype (F(1,90) = 27.79, P = 9.2e-7). Comparisons in (B,D) show the results of false-discovery adjusted t tests as described in the Methods.
