Figure 2
From: Mild chronic perturbation of inhibition severely alters hippocampal function
Faster γ2* deactivation. (A) Response of nucleated patches from N2a cells to 1 ms application of GABA. Upper trace: open tip current showing application speed. (B) Summary. *P = 0.025, two-tailed t test. (C) Voltage-pulse relaxation test of deactivation kinetics. * P Non-GABA currents are subtracted. (D) Tau of tail currents measured at −70 mV (arrows in C). *P = 0.021, two-tailed t test. (E) Sample single-channel records from a cell-attached patch on N2a cells expressing the indicated subunits. Open state is up. The lower panels show log-binned counts of open times from samples of the two subunit variants. The fits are to three components. (F) Average weighted mean open time for each patch. *P = 0.035 two-tailed t test.
