Table 1 Associations between the SNPs and SLE, SSc and AAV under the additive model (case-control analysis).

From: Association of NCF1 polymorphism with systemic lupus erythematosus and systemic sclerosis but not with ANCA-associated vasculitis in a Japanese population

 

n

rs73366469 (T > C)

GTF2I-GTF2IRD1

rs117026326 (C > T)

GTF2I

rs80346167 (G > A)

GTF2IRD1

rs201802880 (G > A)

NCF1

MAF

(%)

Puncorr

(Q)

OR

(95%CI)

MAF

(%)

Puncorr

(Q)

OR

(95%CI)

MAF

(%)

Puncorr

(Q)

OR

(95%CI)

MAF

(%)

Puncorr

(Q)

OR

(95%CI)

SLE all

842

(826)

300

(17.8)

8.47 × 10−14

(6.22 × 10−13)

2.36

(1.89–2.96)

298

(17.7)

7.96 × 10−16

(8.76 × 10−15)

2.60

(2.06–3.29)

376

(22.3)

3.39 × 10−5

(1.86 × 10−4)

1.47

(1.23–1.77)

744

(45.0)

3.77 × 10−44

(8.29 × 10−43)

3.57

(2.99–4.28)

SSc all

467

(326)

115

(12.3)

0.0028

(0.0095)

1.47

(1.14–1.89)

108

(11.6)

0.0035

(0.0095)

1.48

(1.14–1.94)

185

(19.8)

0.0039

(0.0095)

1.25

(1.01–1.54)

174

(26.7)

2.40 × 10–4

(0.0011)

1.50

(1.21–1.87)

AAV all

477

(415)

81

(8.5)

0.78

(0.89)

0.96

(0.72–1.27)

84

(8.8)

0.44

(0.76)

1.12

(0.84–1.48)

185

(19.4)

0.083

(0.17)

1.20

(0.98–1.47)

168

(20.2)

0.73

(0.89)

1.04

(0.84–1.28)

Healthy controls

934

(876)

163

(8.7)

referent

149

(8.0)

referent

313

(16.8)

referent

344

(19.6)

referent

  1. Case-control association analysis was performed using logistic regression test under the additive model using R software. P values (P) and odds ratios (OR) were adjusted for sex. FDR P values (Q) were calculated by Benjamini-Hochberg method. The numbers of the samples in the parentheses show the numbers of those analyzed for rs201802880, after the exclusion of non-amplified samples at the nested PCR process. MAF; minor allele frequency. CI; confidence interval.
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