Figure 3 | Scientific Reports

Figure 3

From: Lack of specific T- and B-cell clonal expansions in multiple sclerosis patients with progressive multifocal leukoencephalopathy

Figure 3

Frequency of TRB and IGH distribution and percentage of the 250 most frequent TRB and IGH sequences. (a) Frequency distributions and (b) cumulative percentage of the 250 most frequent TRB sequences detected by NGS before (T0), during (T1 and T2) natalizumab therapy and at PML development (T3) in PML-NAT#1 and PML-NAT#2; at the time of PML development in PML-NAT#3, PML-NAT#4 and PML-ALEM#5. (c) Frequency distributions and (d) cumulative percentage of the 250 most frequent TRB sequences in natalizumab-treated patients who did not develop PML (MS#1 and MS#2). (e) Frequency distributions and (f) cumulative percentage of the 250 most frequent IGH sequences in PML-NAT#1, PML-NAT#2, PML-NAT#3, PML-NAT#4 and PML-ALEM#5 at PML development (T3).

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