Figure 4

Differentially expressed proteins related to glycolysis and the citric acid cycle in six different 3T3-L1 cells. Down-regulated proteins expression compared to that of 2D mono-cultured preadipocytes (>1.5-fold change) are indicated in blue, and up-regulated proteins (>1.5-fold change) are indicated in pink. Boxes from the left to the right represent 2D mono-cultured preadipocytes (2P), 2D mono-cultured adipocytes (2A), 2D co-cultured adipocytes with macrophages (2C), 3D mono-cultured preadipocytes (3P), 3D mono-cultured adipocytes (3A) and 3D co-cultured adipocytes with macrophages (3C). [*Abbreviations: PDHα, pyruvate dehydrogenase E1 component subunit alpha; PDHβ, pyruvate dehydrogenase E1 component subunit beta; ODP2, ovule development protein 2; CISY, citrate synthase; ACO1, cytoplasmic aconitate hydratase; IDH2, isocitrate dehydrogenase; OGDH, 2-oxoglutarate dehydrogenase; SCSB, succinate-CoA synthetase subunit beta; SDHα, succinate dehydrogenase (ubiquinone) flavoprotein subunit; SDHβ, succinate dehydrogenase (ubiquinone) iron-sulphur subunit; FH, fumarate hydratase; MDH1, malate dehydrogenase, cytoplasmic; MDH2, malate dehydrogenase, mitochondria; PCX, pyruvate carboxylase; ACLY, ATP-citrate synthase; ACACA, acetyl-CoA carboxylase 1; FAS, fatty acid synthase; ACSL1, long-chain-fatty-acid-CoA ligase 1].