Figure 6 | Scientific Reports

Figure 6

From: iTRAQ-Based Quantitative Proteomic Comparison of 2D and 3D Adipocyte Cell Models Co-cultured with Macrophages Using Online 2D-nanoLC-ESI-MS/MS

Figure 6

The correlated network analysis of up-regulated and down-regulated proteins in adipocytes 3D co-cultured with macrophages (3C) versus 2D mono-cultured preadipocytes (2P). Up-regulated and down-regulated proteins were determined based upon an observed >1.5-fold change in expression among biological and technical replicates. The functional interactions of proteins were predicted using the STRING network analysis program. (A) The network of up-regulated proteins in the pink circle is associated with glycolysis/gluconeogenesis and the TCA cycle, and the yellow circle consists of proteins involved in fatty acid metabolism. (B) The network of down-regulated proteins in the blue circle is associated with cellular component organization, and the proteins in the green circle are involved in DNA replication and regulation of the cell cycle.

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