Figure 3 | Scientific Reports

Figure 3

From: Exploring anticancer activity of structurally modified benzylphenoxyacetamide (BPA); I: Synthesis strategies and computational analyses of substituted BPA variants with high anti-glioblastoma potential

Figure 3

Anti-glioblastoma activity and computed physical properties of fenofibrate (FF) and its simple amides. Panel (A) Cell viability (MTT assay) following exposure to the indicated derivatives of FF (25 μM, for 72 hrs). (Panel B) Computed physical properties of fenofibrate and its simple amides. CV = Cell viability (% of control) mean ± SD at 25 μM; ClogP = calculated partitioning; HBD = hydrogen bond donor at pH = 7; HBA = hydrogen bond acceptor at pH = 7; logBB = calculated blood-brain partition; MP = Molecular polarizability(Å3); PSA = Polar surface area (Å2); MPA = Minimal projection area (Å2); LogS = Aqueous solubility (mg/ml); MPO = Central nervous system multiparameter optimization (CNS MPO).

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