Figure 1
From: Functional and topographic effects on DNA methylation in IDH1/2 mutant cancers
Disease specific distribution of hyper- and hypomethylated probes among functional regions. Differential methylation analysis of IDH1/2 mutated AML compared to normal blood (a) and IDH wild-type AML (b), IDH1/2 mutated astrocytoma compared to IDH wild-type GBM (Classic and Mesenchymal subtypes) (c) and IDH mutated oligodendroglioma compared to RTKI (Proneural) GBM (d). Heatmaps show clustering using top 10,000 most differentially methylated probes. Bar plots represent the number of all significant (FDR < 0.05) hyper- and hypomethylated probes (x103) in each IDH mutated tumor when compared to the wild-type counterpart. Gene bodies and enhancers show significantly higher number of hypermethylated probes than promoters while promoters show significantly higher number of hypomethylated probes, across all comparisons. Two-tailed t-test, p-value: *<1 × 10−2, **<1 × 10−3, ***<1 × 10−4 and ****<1 × 10−5.
