Figure 2
From: Functional and topographic effects on DNA methylation in IDH1/2 mutant cancers
DNA Methylation across six IDH1/2 mutant cancers. (a), Supervised hierarchical clustering of acute myeloid leukemia (AML), astrocytoma, breast cancer, cholangiocarcinoma (CC), oligodendroglioma (ODG), and sinonasal undifferentiated carcinoma (SNUC) using top 10,000 differentially methylated probes shows that despite all tumors harboring IDH1 or IDH2 mutations, tumors cluster along the developmental lines with mesenchymal (AML), neuroectodermal (astrocytoma, oligodendroglioma) and epithelial (CC, SNUC and breast carcinoma) cancers. (b,c), Venn diagram shows shared and unique hypermethylated (b) and hypomethylated (c) probes for each disease. AML has the highest number of total and unique hyper- and hypomethylated probes.
