Figure 5
From: Functional and topographic effects on DNA methylation in IDH1/2 mutant cancers
The effect of IDH1/2 mutation induced DNA methylation of cell biology. (a) Hypermethylated promoters show enrichment in GO terms for in meiosis and gamete generation, which likely have no role in cancer growth. (b) Gene bodies and (c) enhancers was enriched for GO terms associated with axonogenesis, dendrite development and neuronal differentiation, Ras signaling, cell morphogenesis GTPase activity as well as cell migration. (d) Hypomethylated promoter probes were associated with basic cellular functions such as RNA processing and cell proliferation. (e) Common hypomethylated probes in gene bodies also showed enrichment in GO terms for such as RNA processing and protein catabolism. (f) Hypomethylated enhancers were enriched for GO terms involved in cell fate commitment, early organ development, pattern specification and morphogenesis suggesting hypomethylation of tissue specific enhancers plays a in blockade of differentiation observed in IDH1/2 mutant cancers.
