Table 2 Performance of PBMC DNA methylation models to predict future radiographic progression in OA patients when evaluating previously unseen data.

From: A pilot study of peripheral blood DNA methylation models as predictors of knee osteoarthritis radiographic progression: data from the Osteoarthritis Initiative (OAI)

 

M-value based models (mean ± SEM)

Beta value-based models (mean ± SEM)

ROC-AUC (c-statistic)

0.81 ± 0.01

0.75 ± 0.01

Accuracy

73 ± 1%

69 ± 1%

Odds ratio

11 ± 2

9 ± 2

Sensitivity

74 ± 1%

73 ± 2%

Specificity

70 ± 1%

70 ± 1%

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