Table 4 Ontology analysis of genes associated with rapid OA progressor DNA methylation models.
Canonical pathway | p-value | Genes associated | |
|---|---|---|---|
Antigen presentation | 7.08E-04 | CIITA,HLA-DPA1,HLA-DPB1,PSMB8,PSMB9,TAP2 | |
AMPK signaling | 1.05E-03 | AK8,CFTR,CHRM2,CHRNA2,CHRNA9,EEF2,FOXG1,INS,PDPK1,PPM1E,PRKACB,RAB7A,RPTOR,SMARCA4,SMARCD3 | |
Sonic hedgehog signaling | 9.33E-03 | GLIS1,GLIS2,PRKACB,SUFU | |
Synaptogenesis Signaling Pathway | 1.58E-02 | AP2A2,CACNB4,CDH22,CDH23,CDH4,EIF4EBP3,EPHA8,EPHB3,FGR,GRIN2B,PRKACB,SHC2,STX1B,SYN2,SYT15,SYT5 | |
Aryl Hydrocarbon Receptor Signaling | 1.95E-02 | ALDH1A3,ARNT,CDK6,CDKN2A,NCOA2, NR2F1,RXRG,SMARCA4,TP73 | |
Endocannabinoid Neuronal Synapse Pathway | 2.75E-02 | CACNB4,CACNG3,CACNG8,CNR2,GNG7,GRIN2B,PRKACB,PTGS2 | |
Autophagy | 2.82E-02 | ATG7,CTSO,LAMP1,SQSTM1,WIPI1 | |
Upstream regulator | Molecule type | p-value | Number of associated genes |
PITX2 | transcription regulator | 1.34E-05 | 14 |
Bvht | long noncoding RNA | 5.48E-05 | 10 |
histone H3 | group | 6.93E-05 | 29 |
histone H4 | group | 9.63E-05 | 14 |
miR-141 | microRNA | 1.91E-04 | 9 |
ASCL1 | transcription regulator | 3.09E-04 | 10 |
miR-9 | microRNA | 3.37E-04 | 5 |
LHX6 | transcription regulator | 4.42E-04 | 5 |
miR-137 | microRNA | 8.23E-04 | 2 |
BMP2 | growth factor | 8.96E-04 | 15 |
