Figure 1 | Scientific Reports

Figure 1

From: Sorsby Fundus Dystrophy Mutation in Tissue Inhibitor of Metalloproteinase 3 (TIMP3) promotes Choroidal Neovascularization via a Fibroblast Growth Factor-dependent Mechanism

Figure 1

Increased laser-induced CNV leakage in TIMP3-S179C+/+ mutant mice. Wild-type (n = 9) and mutant TIMP3-S179C+/+ (n = 10) mice were subjected to laser burns and evaluated by SLO at day 3 and day 7. Mice were injected with NaF and ICG and imaged at “early” and “late” time points to determine leakage area as demarcated by FA- and ICGA-SLO angiography. Representative SLO images of a WT mouse imaged at day 3 (a) FA and ICG early (c) FA and ICG late (e) same lesions in the same WT mouse imaged at day 7 (e) FA and ICG early and (g) FA and ICG late (b) S179C+/+ mouse imaged at day 3 (b) FA and ICG early (d) FA and ICG late (f) same lesions in the same S179C+/+ mouse imaged at day 7 (f) FA and ICG early and (h) FA and ICG late. Quantitation and comparison of CNV leakage area in WT and S179C+/+ mice is depicted in (i) day 3 FA (early and late) (j) day 3 ICG (early and late) (k) day 7 FA (early and late) (l) day 7 ICG (early and late). Representative OCT images are presented for (m) WT and (n) S179C+/+ mice and CNV volume quantitated and compared (o). Data are presented as means ± SD of 1–3 lesions in each mouse of each genotype. Student’s two-tailed t-test **p ≤ 0.03.

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