Figure 2 | Scientific Reports

Figure 2

From: Sorsby Fundus Dystrophy Mutation in Tissue Inhibitor of Metalloproteinase 3 (TIMP3) promotes Choroidal Neovascularization via a Fibroblast Growth Factor-dependent Mechanism

Figure 2

Increased FGFR phosphorylation in the RPE/choroid of S179C+/+ mutant mice is an early event following laser injury. RPE/choroid tissue was collected from wild-type (WT) and S179C+/+ mutant mice (KI) at 3 days following laser injury. Lysates were analyzed for the presence of (a) FGFR-1 and phosphorylated FGFR-1(pFGFR-1) and (b) downstream pERK. Band intensities were quantitated and compared (c–e). Data are presented as means ± SD n = 3. **p ≤ 0.05 vs WT.

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