Figure 3 | Scientific Reports

Figure 3

From: Sorsby Fundus Dystrophy Mutation in Tissue Inhibitor of Metalloproteinase 3 (TIMP3) promotes Choroidal Neovascularization via a Fibroblast Growth Factor-dependent Mechanism

Figure 3

Increased MMP2 activation in RPE/choroid of S179C+/+ mutant mice following laser injury. RPE/choroid tissue from wild-type (WT) and S179C+/+ mutant mice (KI) was collected 3 days following laser injury and subjected to (a) gelatin zymography. Intensity of (b) a-MMP2 and (c) Total-MMP2 from RPE/choroid tissue was evaluated by ELISA and compared between WT and KI mice (n = 3–4). **p ≤ 0.04.

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