Figure 6 | Scientific Reports

Figure 6

From: Sorsby Fundus Dystrophy Mutation in Tissue Inhibitor of Metalloproteinase 3 (TIMP3) promotes Choroidal Neovascularization via a Fibroblast Growth Factor-dependent Mechanism

Figure 6

Decreased TEER and increased apical secretion of bFGF in RPE cells expressing mutant TIMP3. Box and whisker plots depict comparisons between RPE cells expressing empty vector (Vector), wild-type TIMP3 (WT) or mutant S179C-TIMP3 (Mutant) of (a) TEER (b) FGF2 concentration in the apical conditioned medium (c) FGF2 concentration in the basal conditioned medium (d) ratio of apical/basal FGF2 (n = 6–8). **p ≤ 0.01 vs Vector.

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