Figure 1

Schematic representation of the cell model. Either chemical stimulation or flow-induced shear stress results in increased intracellular [IP₃]. IP₃ binds to IP₃R triggering ER Ca²⁺ release. Ca²⁺ is pumped back into the ER via the SERCA or is taken up by the Mt via the MCU. Ca²⁺ is also extruded from the Mt into the intracellular space via the mNCX. IP₃R, MCU, SERCA and mNCX channels face either the µd or Cyt (channels inward to the respective compartment are filled with color; outward channels are not filled). All fluxes, including leaks, are shown. Each compartment contains Ca²⁺ buffering proteins (not shown). This schematic diagram was created using Microsoft PowerPoint (https://products.office.com/en-us/powerpoint).