Figure 2

Bifurcation diagrams with/without the Mt and µd. (A) Bifurcation diagrams without Mt and µd (blue curve), with Mt and without µd (red curve), and with both Mt and µd (black curve). Compartments were inactivated by setting respective fluxes entering and leaving the compartment equal to zero. Addition of the µd resulted in the emergence of an oscillatory region at low levels of IP₃ (magnified in inset of A). (B–D) Traces of \({[{{\rm{Ca}}}^{2+}]}_{{\rm{Cyt}}}^{{\rm{eff}}}\) vs. time are shown with [IP₃] of 0.2, 0.7, and 3 µM (corresponding to regions α, β, and γ, respectively) applied at 50 s. Sustained oscillations occurred following IP₃ stimulation at levels corresponding to regions α (B) and β (C), whereas damped oscillations with elevated [Ca²⁺] levels occurred at high IP₃ levels outside the oscillatory domains (region γ) (D).