Figure 7
From: Modeling the role of endoplasmic reticulum-mitochondria microdomains in calcium dynamics
Dependence of Ca2+ oscillation frequency on CMCU and CIP3R. (A) Heatmap of oscillation frequency as a function of CMCU and [IP3]. At low [IP3] (corresponding to region α, the µd-dominant region), oscillations were present only at select values of CMCU. At higher [IP3] (corresponding to region β, the Cyt-dominant region), the oscillation frequency remained almost unchanged with respect to CMCU. (B) Clamping of JIP3R resulted in loss of oscillatory activity in the Cyt-dominant region, but sustained activity in the µd-dominant region. (C) Clamping of JIP3Rµd resulted in loss of oscillations in the µd-dominant region, but activity was sustained in the Cyt-dominant region. (D,E) Oscillation frequency was computed as a function of CMCU and CIP3R at two [IP3]. (D) In region α, the highest oscillation frequency occurred with CMCU close to 1 and CIP3R of ~0.5. Higher values of CIP3R resulted in loss of oscillations. (E) In region β, the oscillation frequency remained almost unchanged with respect to CMCU, but oscillations were lost at CIP3R > ~0.6.
