Figure 9

Robustness and sensitivity of model output to variations in parameters. (A,B) Partial Rank Correlation Coefficient (PRCC) values of statistically significant parameters taken from 250,000 parameter sets obtained from Latin Hypercube Sampling with uniform distribution. Each parameter was allowed to vary ±40% of its control value in Supplementary Table S1. Out of 250,000 parameter sets, oscillations occurred in ~60,000 sets (~25% of total). Sensitivity of parameters to peak amplitude (A) and frequency (B) are shown. (C–F) Histograms of peak amplitude of [Ca²⁺] oscillations in each compartment. (G) Histogram of frequency of [Ca²⁺]_Cyt oscillations.