Table 4 Statistically significant associations of the frequently mutated genes with clinico-pathological variables.

From: A comprehensive evaluation of pathogenic mutations in primary cutaneous melanomas, including the identification of novel loss-of-function variants

Genes

ARID1A

p-value

ARID2

p-value

PARD3

p-value

Variables

wt

mut

wt

mut

wt

mut

total

108

6

106

8

107

7

Histological subtype

 

0.177

 

0.564

 

0.512

NM

42

4

 

42

4

 

44

2

 

SSM

66

2

 

64

4

 

63

5

 

Tumor stage

 

0.608

 

0.094

 

0.515

pT1 + pT2

26

2

 

28

0

 

27

1

 

pT3 + pT4

82

4

 

78

8

 

80

6

 

Location

 

0.024

 

0.167

 

0.165

Sun non-exposed

68

1

 

66

3

 

63

6

 

Sun exposed

40

5

 

40

5

 

44

1

 

Age

 

0.965

 

0.024

 

0.046

≤median

55

3

 

57

1

 

57

1

 

>median

53

3

 

49

7

 

50

6

 
  1. Sun exposed location = head, lower- and upper extremities; sun non-exposed location = trunk. P-values are based on Chi-squared tests, all significant p-values are indicated in bold. NM – nodular melanoma, SSM - superficial spreading melanoma. The full list of statistical associations of frequently mutated genes with clinic-pathological variables is in Supplementary Table 2.
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