Table 2 Therapeutic effects on the lung bacterial loads at 24 and 48 h after starting the antibiotic agents.

From: In vivo efficacy of combination of colistin with fosfomycin or minocycline in a mouse model of multidrug-resistant Acinetobacter baumannii pneumonia

Antibiotic regimen

24 h

48 h

Control

12.24 ± 0.44

12.99 ± 0.22

COL

9.65 ± 0.43a

8.73 ± 0.34a

FOS

7.68 ± 0.47a

6.68 ± 1.02a

MIN

9.26 ± 0.19a

7.73 ± 1.33a

COL + FOS

5.63 ± 0.26a,b

3.46 ± 0.42a,b,c

COL + MIN

6.07 ± 1.04a,b

5.16 ± 0.83a,b

  1. COL, colistin; MIN, minocycline; FOS, fosfomycin.
  2. The lung bacterial loads are expressed as the mean ± standard deviation of log10 CFU per gram of lung at 24 and 48 h.
  3. aSignificant difference in bacterial load compared with the control group (p < 0.05).
  4. bSignificant difference in bacterial load compared with the more active antibiotic alone (p < 0.05).
  5. cSignificant difference in bacterial load compared with the other combination (p < 0.05).
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