Table 2 Univariable and multivariable Cox regression analysis for prediction of RFS.
Factors | Subgroup | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|---|
HR (95%CI) | P | HR (95%CI) | P | ||
Age | 1.02 (0.99–1.04) | 0.139 | NA | NA | |
Sex | Female | 1 | |||
Male | 0.76 (0.44–1.31) | 0.324 | NA | NA | |
Primary site | Larynx | 1 | |||
Oral tongue | 1.20 (0.54–2.66) | 0.663 | NA | NA | |
Oral cavity | 1.43 (0.53–3.77) | 0.469 | NA | NA | |
Others | 1.77 (0.86–3.62) | 0.121 | NA | NA | |
Smoking history | No | 1 | |||
Yes | 0.76 (0.45–1.27) | 0.295 | NA | NA | |
Alcohol history | No | 1 | |||
Yes | 1.66 (0.90–3.07) | 0.107 | NA | NA | |
History of other malignancy | No | 1 | |||
Yes | 1.05 (0.42–2.62) | 0.917 | NA | NA | |
Lymph node neck dissection | Yes | 1 | |||
No | 1.08 (0.46–2.50) | 0.865 | NA | NA | |
Number of Lymph nodes | ≤45 | 1 | |||
>45 | 1.35 (0.78–2.31) | 0.284 | NA | NA | |
Number of positive LNs | <3 | 1 | 1 | ||
≥3 | 2.95 (1.79–4.88) | 0.000* | 1.90 (1.12–3.21) | 0.017* | |
Margin status | Negative | 1 | 1 | ||
Positive | 2.87 (1.71–4.81) | 0.000* | 2.11 (1.24–3.61) | 0.06* | |
Tumor grade | G1-G2 | 1 | |||
G3-G4 | 0.86 (0.47–1.58) | 0.63 | NA | NA | |
Clinical T stage | T1-T2 | 1 | |||
T3-T4 | 1.48 (0.85–2.58) | 0.162 | NA | NA | |
Clinical N stage | N0 | 1 | |||
N1-N3 | 1.25 (0.75–2.09) | 0.40 | NA | NA | |
Clinical TNM stage | I-II | 1 | |||
III-IV | 1.64 (0.81–3.34) | 0.170 | NA | NA | |
Mutation count | ≤65 | 1 | |||
>65 | 2.34 (1.06–5.13) | 0.035* | 2.56 (1.14–5.72) | 0.022* | |
Fraction Genome altered | ≤0.29 | 1 | |||
>0.29 | 1.10 (0.65–1.86) | 0.724 | NA | NA | |
LncRNA classifier | Low risk | 1 | 1 | ||
High risk | 4.97 (2.64–9.35) | 0.000* | 4.72 (2.48–9.0) | 0.000* | |
