Figure 2 | Scientific Reports

Figure 2

From: A new model isolates glioblastoma clonal interactions and reveals unexpected modes for regulating motility, proliferation, and drug resistance

Figure 2

The U87MG cell line is clonally heterogeneous. (A) Unsupervised two-way hierarchical clustering of protein phosphorylation and abundance for 23 subclones of the U87MG cell line reveals six subtypes (*clones selected for further investigation). (B–E) Highest and lowest (phospho)protein abundance quartiles for subtype 1 and 5. Protein-protein interactions as predicted by STRING were plotted using Gephi, with radial arms representing separate protein interaction clusters based on modularity. Node size and order is reflecting degree (number of connections per node), while color shade corresponds to protein abundance level (proteins described by gene names as understood by STRING, red = highest quartile, blue = lowest quartile).

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