Figure 4 | Scientific Reports

Figure 4

From: A new model isolates glioblastoma clonal interactions and reveals unexpected modes for regulating motility, proliferation, and drug resistance

Figure 4

Tumor cell clones coordinate their migration. (A–D) In a 2D wound healing assay, clone C inhibits migration of any other clone present while increasing its own migration. (E–H) 3D spheroid outgrowth onto cell culture treated plastic demonstrates significant inhibition of migration of any clone co-localized with clone C. (I) Representative images of spheroid outgrowth of clones C and E either alone (top panel) or mixed (bottom panel). (*p < 0.05 for indicated pairs; #,&p < 0.05 versus respective clone in mix).

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