Figure 6 | Scientific Reports

Figure 6

From: A new model isolates glioblastoma clonal interactions and reveals unexpected modes for regulating motility, proliferation, and drug resistance

Figure 6

Tumor cell clones cooperate to resist treatment. (A–D) Cooperation between clone C and clone E leads to treatment resistance against docetaxel. (E–H) Clone C is significantly more resistant to treatment with cisplatin when cooperating with clone E or B, while neither clone E or B benefit from this cooperation against cisplatin treatment. (A,C,E,G)=raw effect of drug treatment, disregarding differences in clonal growth rate and the change in growth rate that is observed when clones are mixed; (B,D,F,H)=adjusted effect that accounts for clonal growth rates. (*p < 0.05 for indicated pairs; #,&p < 0.05 versus respective clone in mix; each experiment was repeated at least three times, representative experiment shown).

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