Table 1 Fibrosis and Wnt-related gene expression for RLX treated atria.

From: Relaxin reverses maladaptive remodeling of the aged heart through Wnt-signaling

Protein

Gene

Expression

n/group

p

MMP-2

MMP2

−43 ± 13%

8

0.004

MMP-9

MMP9

−41 ± 17%

18

0.02

αSMA

ACTA2

−27 ± 18%

18

0.04

Wnt-1

WNT1

+80 ± 16%

18

0.01

  1. *Relative to aged control.
  2. Relaxin altered expression of mRNA in aged atria that relate to fibrotic and Wnt related genes. Data were obtained by quantitative RT-PCR as described under Methods. Data are reported as percent change of mRNA levels obtained from RLX-treated aged atria relative to vehicle-treated aged controls ± standard deviation (n = number of rats/hearts per group).
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