Table 1 Clinical data.

From: FGF Signalling in the Self-Renewal of Colon Cancer Organoids

ID

Gender

Age

Location sampled tissue

UICC

Primary Tumour (TNM)

Differentiation

Pre-treatment

BRAF/NRAS/KRAS

Patient 1

M

62

Liver

IV

pT2 pN1 M1hep

Moderate

5-FU, Oxaliplatin, Bevacizumab

wt/wt/G12D

Patient 2

M

64

para rectal LN

IV

pT2 pN2 M1hep

Moderate

5-FU, Oxaliplatin, Cetuximab

wt/wt/wt

Patient 3

F

81

Sigmoid

IV

pT3 pN1 M1hep

Moderate

/

wt/G12V/wt

Patient 4

M

51

Sigmoid

IB

pT2 pN0 M0

Poor

/

wt/G12S/wt

Patient 5

F

59

Rectum

IB

pT2 pN0 M0

Well

Capecitabine, Radiotherapy (50,4 Gy)

 

Patient 6

F

58

Rectum

 

HGIEN

 

/

 

Patient 7

F

85

Rectum

IIA

pT3 pN0 M0

Well

/

 

Patient 8

M

74

Liver

IV

pT2 pN0 M1hep

Moderate

/

 

Patient 9

M

75

Sigmoid

IIA

pT3 pN0 M0

Well

/

 
  1. Clinical data of sampled patients. Organoid cultures could be established from patients 1, 2, 3, 4. Only after successful culture establishment mutational hotspots of the BRAF, NRAS, KRAS loci were sequenced. HGIEN = high-grade intra-epithelial neoplasia; M = male, F = female, LN = lymph node, 5-FU = 5-Fuoruracil, wt = wild-type.