Figure 5
15-HPGD knockout mice have normal levels of PGE2 but increased levels of PGF2α and decreasing levels of serum progesterone at the time of pregnancy loss. (A) implantation site PGF2α concentrations in the wild type (triangle) and the KO at dpc 6.5, 7.5 and 8.0. *P < 0.01. (B) implantation site PGF2α concentrations in the wild type (triangle) and the KO at dpc 6.5, 7.5 and 8.0. (C) serum progesterone concentrations in the wild type (triangle) and the KO at dpc 6.5, 7.5 and 8.0%, # designate samples from the same mouse in (A–C). n = 3 (D) serum progesterone concentrations correlate inversely with local PGF2α concentrations in the wild type (square) and the KO (triangle) at dpc 6.5 (red), 7.5 (green) and 8.0 (blue), n = 3.
