Figure 3
From: A framework for identification of on- and off-target transcriptional responses to drug treatment
Off-target canonical KEGG pathways in statin-treated cells. The matrix (pathways by samples) displays the off-target effects in at least one condition. Orange, green, red, blue and white indicate on-target up-regulated, on-target down-regulated, off-target up-regulated, off-target down-regulated and non-significantly altered pathways respectively. Abbreviations: Ato: Atrovastatin; Flu: Fluvastatin; Ros: Rosuvastatin; Sim:Simvastatin. In silico validation and and whether the effect has been previously observed in the literature is also indicated.
